Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. Jul-Aug 2010;22(4):284-9.
doi: 10.1038/ijir.2010.17. Epub 2010 Jul 1.

Hardness, function, emotional well-being, satisfaction and the overall sexual experience in men using 100-mg fixed-dose or flexible-dose sildenafil citrate

Affiliations
Free PMC article
Comparative Study

Hardness, function, emotional well-being, satisfaction and the overall sexual experience in men using 100-mg fixed-dose or flexible-dose sildenafil citrate

P Ströberg et al. Int J Impot Res. .
Free PMC article

Abstract

The prescribing information for sildenafil citrate (VIAGRA, Pfizer, New York, NY, USA) recommends flexible dosing (50 mg initially, adjusted to 100 or 25 mg based on effectiveness and tolerability) in most men with erectile dysfunction (ED). In many men, however, 100 mg may be the most appropriate initial dose because it would reduce the need for titration and could prevent discouragement and treatment abandonment should 50 mg be insufficient. Results of two previously published double-blind, placebo-controlled sildenafil trials of similar design except for a fixed-dose vs flexible-dose regimen were analyzed. Relative to the flexible-dose, approximately one-third more men were satisfied with an initial and fixed dose of 100 mg. In addition, tolerability was similar, and improvements from baseline in outcomes on validated, ED-specific, patient-reported questionnaires were either similar (erectile function and the percentage of completely hard and fully rigid erections) or greater (emotional well-being and the overall sexual experience). The similarity in outcomes is not surprising given that almost 90% of the men in the flexible-dose trial titrated to 100 mg after 2 weeks. These data suggest prescription of an initial dose of 100 mg for men with ED, except in those for whom it is inappropriate.

Similar articles

See all similar articles

Cited by 4 articles

References

    1. VIAGRA . Full Prescribing Information, Sildenafil Citrate. Pfizer, Inc.: New York, NY; 2008.
    1. King R, Juenemann KP, Levinson IP, Stecher VJ, Creanga DL. Correlations between increased erection hardness and improvements in emotional well-being and satisfaction outcomes in men treated with sildenafil citrate for erectile dysfunction. Int J Impot Res. 2007;19:398–406. - PubMed
    1. Steidle C, McCullough A, Kaminetsky J, Crowley A, Siegel R, Deriesthal H, et al. Early sildenafil dose optimization and personalized instruction improves the frequency, flexibility, and success of sexual intercourse in men with erectile dysfunction. Int J Impot Res. 2007;19:154–160. - PubMed
    1. Jiann BP, Yu CC, Su CC, Huang JK. Rechallenge prior sildenafil nonresponders. Int J Impot Res. 2004;16:64–68. - PubMed
    1. Lowy M, Collins S, Bloch MT, Gillman M, Lording DW, Sutherland P, et al. Quality of erection questionnaire correlates: change in erection quality with erectile function, hardness, and psychosocial measures in men treated with sildenafil for erectile dysfunction. J Sex Med. 2007;4:83–92. - PubMed

Publication types

MeSH terms

Feedback